Batches of prednisolone tablets recalled over swollen blister packaging

Activase Pharmaceuticals has issued a precautionary recall of two batches of prednisolone 5mg soluble tablets after reports of blister pockets becoming swollen over time.

The recall of the steroid, which is used to reduce inflammation, was announced by the Medicines and Healthcare products Regulatory Agency (MHRA) and is being carried out at pharmacy and wholesaler level only.

It affects batches 2409006 and 2409007 of the 30-tablet packs, both of which have an expiry date of 31 May 2027. The products were first distributed in March and May 2025 respectively.

The swelling is caused by a gradual reaction between excipients in the tablets and trace amounts of moisture, resulting in a build-up of carbon dioxide gas within the blister pockets.

Activase said the issue is confined to the affected batches and does not impact the quality of the tablets themselves.

Healthcare professionals have been advised to stop supplying the affected batches immediately, quarantine any remaining stock, and return it through the usual process.

Patients should continue taking the tablets unless the blister strips show visible signs of swelling, in which case they should return the product to their pharmacy.

The MHRA advised that any patients concerned about their medication should speak to a pharmacist.